Figure 9.

GBM was sensitized to RT with anti-TGM2 blockade (Cys-D) treatment. (A) Schematic of experimental design. (B) Kaplan–Meier survival curves of U251R xenograft-bearing mice from the day of tumor cells implantation to mice death or maximum study duration of 60 days (n = 5 per group). Survival differences were determined by log-rank Mantel-Cox test. (C) Tumor growth delay curves with U251R xenograft tumor volumes measured by MRI scan. (D) U251R xenograft tumor volume was measured by T2-weighted MR image on day 15 (upper panel) and day 30 (lower panel) after cell implantation. Mice were treated with RT, Cys-D, or their combination. Scale bars: 2 mm. (E) Whole mount HE-stained brain sections of mice treated with RT, Cys-D, or their combination. (F-G) Time responses upon the weight of mice after U251R cells implantation on average (F) and individual (G). Mice were treated with RT, Cys-D, or their combination. *P < 0.05 and **P < 0.01.