Table 1.

Clinical data of the patient’s family.

Patient	Age of onset (years)	Course of disease (years)	First symptom	Main clinical manifestations	Related inspection	Pathology	Genetic analysis
2A (father)	56	4	Psychiatric symptoms (depression, hallucinations)	Unstable gait, dysarthria, dysphagia, muscle atrophy of both lower extremities, advanced severe dementia, and two obstacles	Unknown	Not done	Not done
1B (proband)	54	≥1	Psychiatric symptoms (depression, emotional fluctuations)	Unstable gait, psychiatric symptoms, dementia, and dysfunction in recent follow-up	See case data for details	Not done	P102L mutation in PRNP gene
1C (daughter)	32 (Currently without symptoms)	–	–	–	–	–	P102L mutation in PRNP gene