Figure 2.

Proteases implicated in IBD, IBS, CeD and GI infections. In disease-related conditions, proteases induce structural and functional changes in the gut through multiple mechanisms of action, including effects on dietary protein metabolism, mucosal barrier function, neuronal excitability and immunoregulation. Luminal proteases impact GI function by a combination of PAR-dependent and independent effects. Proteases of microbial origin are highlighted in red. *Proteases with therapeutic potential. Figure was created with BioRender.com.