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. 2023 Feb 22;18(1):2175522. doi: 10.1080/15592294.2023.2175522

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — UCHL1 promoter methylation and mRNA expression in airway epithelium from non-smokers, smokers, and ex-smokers obtained by LCM. (a) Schematic representation of the CpG island of the UCHL1 gene, outlining the CpG sites around the TSS. The TSS is shown as +1. (b) Bronchial airway epithelium from non-smokers, smokers, and ex-smokers was collected by LCM, (n = 6 per group) and DNA methylation of seven CpG sites was analysed by pyrosequencing. Data represent the connected median methylation levels at different CpG sites (n = 6). (c) The percentage of methylation at CpG site #6 (+9 bp) for each group is indicated. Significance was analysed by nonparametric Mann-Whitney U-test, *p < 0.05.