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. 2022 Oct 28;22(6):680–692. doi: 10.1080/15384101.2022.2139554

Figure 5.

Figure 5.

miR-140-3p targets and downregulates USP36. (a) Binding sites and corresponding mutant sites of miR-140-3p and USP36 3’ UTR. (b) Venn diagram displaying miR-140-3p computationally predicted to target USP36 by TargetScan, miRwalk, and Oncomir databases. (c) Dual luciferase activity assay was performed by co-transfection of luciferase reporter containing USP36 3’ UTR or the mutant reporter with miR-140-3p mimics. (d) Dual luciferase activity assay was performed by co-transfection of luciferase reporter containing USP36 3’ UTR or the mutant reporter with miR-140-3p inhibitor. (e) the effect of miR-140-3p on USP36 mRNA expression. (f, g) the effect of miR-140-3p on USP36 protein expression. *P < 0.05.

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