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. 2022 Nov 25;22(6):633–644. doi: 10.1080/15384101.2022.2147655

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Cleavage furrow formation and ingression during cytokinesis in mammalian cells. Schematic representation of cells in anaphase (left) and telophase (right). (a) Anillin functions in connecting the spindle MT with the ACR through interactions with RhoA (see (b) for labels). (b) RhoA GTP-dependent activity is induced by interactions with the MgcRacgap and ECT2, after which leads to polymerization of actin filaments and induction of the phosphorylation-dependent myosin-II activation; these events lead to the formation and ingression of the cleavage furrow through interactions between myosin heads and actin filaments. See main text for references.