Skip to main content
. 2023 Feb 17;12:e81850. doi: 10.7554/eLife.81850

Figure 3. The number of predicted key allo-residues.

Number of residues refers to the number of residues from allosteric pockets, including the number of all residues in allosteric pockets and predicted key allo-residues.

Figure 3—source data 1. Raw data for Figure 3.

Figure 3.

Figure 3—figure supplement 1. Distribution of the ratios of the number of key allo-residues predicted by KeyAlloSite in the number of all residues in allosteric pockets when using different cutoffs in all proteins.

Figure 3—figure supplement 1.

Figure 3—figure supplement 1—source data 1. Raw data for Figure 3—figure supplement 1.
Figure 3—figure supplement 2. Examples of distributions of the statistics corresponding to significant scores obtained from the t-test.

Figure 3—figure supplement 2.

These three distributions are the distributions of the statistics in BCR-ABL1, Tar, and PDZ3.
Figure 3—figure supplement 3. Random sampling of homologous sequences.

Figure 3—figure supplement 3.

For each of the seven proteins, we randomly sampled different numbers of homologous sequences such as 1 L, 2 L, and so on. The ratio refers to the proportion of identical key allo-residues identified by all and different numbers of homologous sequences. The process was repeated three times, and the mean and standard deviation of the ratios were calculated. L: length of protein.
Figure 3—figure supplement 3—source data 1. Raw data for Figure 3—figure supplement 3.