Table 2.
Clinical sensitivity and specificity at each study site. NA is not applicable as the site did not perform the assay. The 95% confidence interval is showed in parenthesis.
| Study site | RdRP sensitivity (%) | RdRP specificity (%) | N sensitivity (%) | N specificity (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <30 Ct | 30–35 Ct | >35 Ct | Overall | <30 Ct | 30–35 Ct | >35 Ct | Overall | |||
| IPD | 100 (95 – 99.9) |
75 (47.6 –92.7 |
21.4 (4.7 – 50.8) |
85.3 (76.9 – 91.5) |
99 (97.4 – 99.7) |
98.6 (92.5 – 99.9) |
81.2 (54.3 – 95.9) |
14.3 (1.8 –42.8) |
84.3 (75.8 – 90.8) |
99 (97.8 – 99.8) |
| IPM | 94.4 (89.3 – 97.5) |
23.9 (12.6 –38.7) |
4.2 (0.5 – 14.2) |
62.4 (55.9 – 68.6) |
93.5 (89.8 – 96.2) |
82.5 (75.3 – 88.3) |
10.8 (3.6 –23.6) |
12.5 (4.7 –25.2) |
54,4 (47.9 –60.9) |
94.3 (90.8 – 96.8) |
| KCCR | 95.6 (78 – 99.9) |
84 (63.9 – 95.5) |
47.6 (25.7 – 70.2) |
76.8 (65 –86.1) |
99.7 (98.7 – 100) |
91.3 (72 – 98.9) |
68 (46.5 – 85) |
19 (5.4 – 41.9) |
60.8 (48.4 – 72.4) |
99 (97.6 –99.7) |
| UI | 95.5 (84.8 –99.5) |
90 (55.5 –99.7) |
42.9 (9.9 – 81.6) |
88.7 (78.1 – 95.3) |
100 (99.1–100) |
95.5 (84.8 –99.5) |
90 (55.5 –99.7) |
42.9 (9.9 – 81.6) |
88.7 (78.1 – 95.3) |
100 (99.1 – 100) |
| INRB | 89.2 (79.8 – 95.2) |
50 (28.2 –71.8) |
3.6 (0.1 –18.3) |
62.9 (53.8 – 71.4) |
99.6 (97.9 – 100) |
25 (8.7 – 49.1) |
16.6 (0.4 – 64.1) |
0 (0 –70.7) |
20.4 (8 – 39.7) |
100 (96 – 100) |
| UofK | 60.5 (40.4 – 76) |
23 (5 – 53.8) |
14.3 (4 – 32.7) |
38 (27.3 – 49.6) |
91.1 (87.2 – 94.3) |
55.3 (38.3 –71.4) |
28.6 (8.4 – 58.1) |
0 (0 – 30.9) |
30.8 (21.1 – 42.1) |
98.5 (96.4 – 99.6) |
| MAK | 87.9 (79.8 – 95.6) |
32 (19.5 – 46.7) |
6.5 (1.4 – 18) |
54.3 (47.09 – 61.5) |
99.3 (97.4 – 99.9) |
NA | NA | NA | NA | NA |