Summary of findings 2. Anxiolytics compared to inactive control for central sleep apnoea associated with heart failure in adults.
| Buspirone 15 mg (3 times daily) compared to inactive control for central sleep apnoea in adults | |||||
| Patient or population: adults with central sleep apnoea associated with heart failure Setting: outpatients Intervention: buspirone 15 mg (3 times daily) Comparison: placebo | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with placebo | Risk with buspirone | ||||
|
cAHI Follow‐up: mean 1 week (short‐term) |
Median difference between groups was −5.00 events/hour (IQR −8.00 to −0.50). The study reported median and IQRs due to skewed data distribution, so did not compare differences between groups. |
16 (1 RCT) | — | ||
| Cardiovascular mortality | Not reported | ||||
| Serious adverse events | Not reported | ||||
| Quality of sleep | Not reported | ||||
| Quality of life | Not reported | ||||
| AHI Follow‐up: 1 week (short‐term) | Median difference between groups was −6.00 (IQR −8.80 to −1.80). The study reported median and IQRs due to skewed data distribution, so did not compare differences between groups. |
16 (1 RCT) | — | ||
| All‐cause mortality | Not reported | ||||
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). AHI: apnoea‐hypopnoea index; cAHI: central apnoea‐hypopnoea index; CI: confidence interval; IQR: interquartile range. | |||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||