Summary of findings 4. Hypnotics compared to inactive control for primary central sleep apnoea in adults.
| Triazolam 0.125 mg or 0.250 mg (once daily)compared to placebo for primary central sleep apnoea in adults | |||||
| Patient or population: adults with primary central sleep apnoea Setting: outpatients Intervention: triazolam 0.125 mg or 0.250 mg (once daily) Comparison: placebo | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with placebo | Risk with triazolam | ||||
|
cAHI Follow‐up: 3 days (short‐term) |
Mean cAHI was 9.40 events/hour in participants who received triazolam 0.125 mg versus 8.00 events/hour in those who received triazolam 0.250 mg versus 16.30 events/hour in those who received placebo. We could not compare the groups because the study did not report SDs for the treatment effects. |
5 (1 RCT) | — | ||
| Cardiovascular mortality | Not reported | ||||
| Serious adverse events | Not reported | ||||
| Quality of sleep | Not reported | ||||
| Quality of life | Not reported | ||||
| AHI Follow‐up: 3 days (short‐term) | Mean AHI was 13.50 events/hour in the participants who received triazolam 0.125 mg versus 11.00 events/hour in those who received triazolam 0.25 mg versus 20.90 events/hour in those who received placebo. We could not compare the groups because the study did not report SDs for the treatment effects. |
5 (1 RCT) | — | ||
| All‐cause mortality | Not reported | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). AHI: apnoea‐hypopnoea index; cAHI: central apnoea‐hypopnoea index; CI: confidence interval; RCT: randomised controlled trial; SD: standard deviation. | |||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||