NCT04118387.

Study name	CSA: physiologic mechanisms to inform treatment
Methods	RCT with a cross‐over design
Participants	People with CSA, defined as AHI >15 events/hour with cAHI > 5 events/hour
Interventions	Acetazolamide + supplemental oxygen + PAP therapy versus zolpidem + PAP therapy versus buspirone + PAP therapy
Outcomes	cAHI
Starting date	7 January 2021
Contact information	sbadr@med.wayne.edu
Notes	Recruitment status: recruiting

AHI: apnoea‐hypopnoea index; cAHI: central apnoea‐hypopnoea index; CHF: chronic heart failure; CSA: central sleep apnoea; PAP: positive airway pressure; RCT: randomised controlled trial.