Supplementary Table 1. High bleeding risk definitions.
| J-HBR criteria | Criteria in the present study | Category | Comments |
|---|---|---|---|
| Age ≥ 75 years | Age ≥ 75 years | Minor | Identical |
| Anticipated use of long-term OAC | OAC use at discharge | Major | Modified |
| Severe CKD (eGFR ＜30 ml/min) | eGFR ＜30 ml/min | Major | Identical |
| Moderate CKD (eGFR 30-59 ml/min) | eGFR 30-＜60 ml/min | Minor | Identical |
| Hemoglobin ＜11 g/dl | Hemoglobin ＜11 g/dl | Major | Identical |
| Hemoglobin 11-12.9 g/dl for men | Hemoglobin 11-12.9 g/dl for men | Minor | Identical |
| Hemoglobin 11-11.9 g/dl for women | Hemoglobin 11-11.9 g/dl for women | ||
| Bleedings requiring hospitalization or transfusion in the past 6 months | N/A | Major | N/A |
| Bleedings requiring hospitalization or transfusion in the past 6 months not meeting the major criterion | Prior gastrointestinal bleeding at any time | Minor | Modified |
| Thrombocytopenia (Plt ＜100×109/l) | Thrombocytopenia (Plt ＜100×109/l) | Major | Identical |
| Chronic bleeding diathesis | N/A | Major | N/A |
| LC with portal hypertension | LC | Major | Modified |
| Long-term use of NSAIDs or steroids | NSAIDs or steroids use at discharge | Minor | Modified |
| Active malignancy (excluding non-melanoma skin cancer) within the past 12 months | Active malignancy at baseline | Major | Modified |
| Previous spontaneous intracranial hemorrhage (at any time); Traumatic intracranial hemorrhage within the past 12 months; Brain arteriovenous malformation; Moderate or severe ischemic stroke within the past 6 months | History of intracranial hemorrhage at any time | Major | Modified |
| Any ischemic stroke at any time not meeting the major criterion | History of ischemic stroke without intracranial hemorrhage at any time | Minor | Identical |
| Non-deferrable major surgery on DAPT | N/A | Major | N/A |
| Recent major surgery or trauma within 30 days before PCI | N/A | Major | N/A |
|
Low body weight (＜55 kg for men and ＜50 kg for women) or frailty |
Low body weight (＜55 kg for men and ＜50 kg for women) |
Major | Modified |
| Peripheral vascular disease | Peripheral artery disease | Major | Modified |
| Heart failure | Heart failure | Major | Identical |
CKD, chronic kidney disease; DAPT, dual antiplatelet therapy; eGFR, estimated glomerular filtration rate; J-HBR, Japanese version of the high bleeding risk; LC, liver cirrhosis; NSAIDs, non-steroidal anti-inflammatory drugs; N/A, not applicable; OAC, oral anticoagulation; PCI, percutaneous coronary intervention; Plt, platelet count.