Table 4.
Univariate and multivariate analyses on the postPSM cohort according to whether or not surgery.
| Characteristics | OS | CSS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | 95%CI lower | 95%CI upper | P | Multivariate analysis | 95%CI lower | 95%CI upper | P | Univariate analysis | 95%CI lower | 95%CI upper | P | Multivariate analysis | 95%CI lower | 95%CI upper | P | ||
| Age | 23–66 | 1 | 1 | 1 | 1 | ||||||||||||
| 67–74 | 1.071 | 0.963 | 1.192 | .207 | 1.122 | 1.005 | 1.252 | .040 | 1.015 | 0.904 | 1.139 | .806 | 1.041 | 0.925 | 1.172 | .501 | |
| 75–97 | 1.565 | 1.391 | 1.761 | <.001 | 1.406 | 1.242 | 1.591 | <.001 | 1.475 | 1.298 | 1.676 | <.001 | 1.295 | 1.134 | 1.480 | <.001 | |
| Tumor size（mm） | 1–44 | 1 | 1 | 1 | 1 | ||||||||||||
| 45–70 | 1.023 | 0.924 | 1.132 | .661 | 1.027 | 0.928 | 1.138 | .604 | 1.095 | 0.981 | 1.222 | .105 | 1.094 | 0.979 | 1.222 | .111 | |
| 71–550 | 1.266 | 1.123 | 1.428 | <.001 | 1.354 | 1.198 | 1.531 | <.001 | 1.361 | 1.196 | 1.549 | <.001 | 1.431 | 1.255 | 1.633 | <.001 | |
| Chemotherapy | No | 1 | 1 | 1 | 1 | ||||||||||||
| Yes | 0.441 | 0.395 | 0.492 | <.001 | 0.573 | 0.498 | 0.660 | <.001 | 0.441 | 0.392 | 0.497 | <.001 | 0.557 | 0.479 | 0.648 | <.001 | |
| Radiation | NO | 1 | 1 | 1 | 1 | ||||||||||||
| Yes | 0.497 | 0.448 | 0.552 | <.001 | 0.631 | 0.553 | 0.72 | <.001 | 0.499 | 0.446 | 0.558 | <.001 | 0.638 | 0.553 | 0.735 | <.001 | |
| Surgery | NO | 1 | 1 | 1 | 1 | ||||||||||||
| Yes | 0.638 | 0.583 | 0.699 | <.001 | 0.585 | 0.533 | 0.72 | <.001 | 0.615 | 0.558 | 0.678 | <.001 | 0.562 | 0.509 | 0.622 | <.001 | |
| N stage | N0 | 1 | 1 | ||||||||||||||
| N1 | 1.035 | 0.865 | 1.238 | .708 | 1.024 | 0.843 | 1.243 | .843 | |||||||||
| T stage | T3 | 1 | 1 | 1 | 1 | ||||||||||||
| T4 | 1.123 | 1.009 | 1.249 | .034 | 1.140 | 1.022 | 1.272 | .019 | 1.159 | 1.034 | 1.300 | .011 | 1.172 | 1.043 | 1.317 | .008 | |
| Grade | I | 1 | 1 | 1 | <.001 | 1 | |||||||||||
| II | 1.228 | 0.992 | 1.52 | .060 | 1.296 | 1.045 | 1.607 | .018 | 1.438 | 1.122 | 1.843 | .004 | 1.512 | 1.178 | 1.941 | .001 | |
| III | 1.448 | 1.173 | 1.787 | .001 | 1.523 | 1.232 | 1.884 | <.001 | 1.735 | 1.358 | 2.217 | <.001 | 1.809 | 1.413 | 2.315 | <.001 | |
| IV | 1.693 | 1.184 | 2.421 | .004 | 1.634 | 1.141 | 2.342 | .007 | 2.125 | 1.439 | 3.137 | <.001 | 2.035 | 1.376 | 3.001 | <.001 | |
| Sex | Female | 1 | 1 | 1 | 1 | ||||||||||||
| Male | 1.215 | 1.080 | 1.366 | .001 | 1.347 | 1.191 | 1.522 | <.001 | 1.228 | 1.081 | 1.395 | .002 | 1.335 | 1.169 | 1.525 | <.001 | |
| Race | White | 1 | 1 | 1 | |||||||||||||
| Black | 1.228 | 1.051 | 1.435 | .010 | 1.217 | 1.034 | 1.431 | .1018 | 1.223 | 1.034 | 1.447 | .019 | |||||
| Other | 0.995 | 0.825 | 1.201 | .962 | 0.982 | 0.812 | 1.1186 | .848 | 1.068 | 0.878 | 1.301 | .510 | |||||
| Histologic | Adenocarcinoma | 1 | 1 | ||||||||||||||
| Squamous cell carcinoma | 0.990 | 0.896 | 1.093 | .843 | 0.970 | 0.871 | 1.080 | .576 | |||||||||
| Other | 0.929 | 0.809 | 1.066 | .294 | 0.944 | 0.814 | 1.094 | .445 | |||||||||
| Primary site | Upper | 1 | 1 | 1 | 1 | ||||||||||||
| Middle | 1.254 | 0.967 | 1.626 | .087 | 1.346 | 1.036 | 1.749 | .026 | 1.347 | 1.1012 | 1.792 | .041 | 1.492 | 1.119 | 1.990 | .006 | |
| Lower | 1.083 | 0.851 | 1.377 | .517 | 1.157 | 0.906 | 1.477 | .243 | 1.152 | 0.883 | 1.504 | .297 | 1.243 | 0.949 | 1.628 | .114 | |
| Other | 1.213 | 0.934 | 1.574 | .148 | 1.192 | 0.916 | 1.551 | .191 | 1.279 | 0.959 | 1.706 | .094 | 1.283 | 0.960 | 1.714 | .092 | |
| Marital status | Unmarried | 1 | 1 | 1 | 1 | ||||||||||||
| Married | 0.847 | 0.733 | 0.929 | <.001 | 0.812 | 0.739 | 0.893 | <.001 | 0.881 | 0.798 | 0.973 | .012 | 0.839 | 0.758 | 0.929 | .001 | |
According to the results of univariate analysis, we included factors with P < .05 into multivariate analysis. We found that the independent factors including age, tumor size, chemotherapy, radiation, surgery, T stage, grade, gender and marital status.
CI = confidence interval, PSM = propensity score matching.