TABLE 1.
Baseline characteristics stratified by different trajectories.
| Characteristic | Total | Class 1 | Class 2 | Class 3 | P-value |
| N = 798 | N = 661 | N = 102 | N = 35 | ||
| Age (y) | 75.00 (70.00–80.00) | 74.00 (70.00–80.00) | 76.00 (74.00–81.00) | 76.00 (70.00–81.00) | 0.017 |
| Male (%) | 456 (57.14) | 374 (56.58) | 61 (59.80) | 21 (60.00) | 0.78 |
| BMI (kg/m2) | 22.80 (20.30–25.00) | 23.10 (20.80–25.30) | 20.75 (19.02–23.40) | 21.40 (19.65–24.35) | <0.01 |
| Smoker (%) | 142 (17.79) | 122 (18.46) | 14 (13.73) | 6 (17.14) | 0.51 |
| STS score (%) | 4.63 (2.79–8.30) | 4.17 (2.55–7.08) | 8.47 (5.28–12.35) | 9.46 (5.79–15.03) | <0.01 |
| Hypertension (%) | 427 (53.51) | 357 (54.01) | 53 (51.96) | 17 (48.57) | 0.78 |
| Diabetes (%) | 164 (20.55) | 142 (21.48) | 18 (17.65) | 4 (11.43) | 0.26 |
| AF (%) | 131 (16.42) | 98 (14.83) | 27 (26.47) | 6 (17.14) | 0.01 |
| COPD (%) | 176 (22.06) | 147 (22.24) | 24 (23.53) | 5 (14.29) | 0.5 |
| PVD (%) | 109 (13.66) | 86 (13.01) | 15 (14.71) | 8 (22.86) | 0.22 |
| Previous stroke (%) | 36 (4.51) | 28 (4.24) | 6 (5.88) | 2 (5.71) | 0.62 |
| Previous PCI (%) | 95 (11.90) | 75 (11.35) | 9 (8.82) | 11 (31.43) | <0.01 |
| Previous MI (%) | 11 (1.38) | 8 (1.21) | 0 (0.00) | 3 (8.57) | 0.01 |
| Previous CABG (%) | 2 (0.25) | 2 (0.30) | 0 (0.00) | 0 (0.00) | 0.99 |
| NYHA Class | <0.01 | ||||
| 1 | 11 (1.38) | 11 (1.67) | 0 (0.00) | 0 (0.00) | |
| 2 | 131 (16.42) | 122 (18.46) | 3 (2.94) | 6 (17.14) | |
| 3 | 400 (50.13) | 360 (54.46) | 28 (27.45) | 12 (34.29) | |
| 4 | 256 (32.08) | 168 (25.42) | 71 (69.61) | 17 (48.57) | |
| NT-proBNP (pg/mL) | 2117.50 (612.25–6182.75) | 1423.00 (466.00–3520.00) | 17727.50 (13637.25–25312.75) | 35000.00 (10078.00–35000.00) | <0.01 |
| eGFR (ml/min) | 56.02 (42.09–73.22) | 60.74 (46.09–76.73) | 41.61 (30.65–51.42) | 28.63 (12.39–40.61) | <0.01 |
| LVEF (%) | 58.90 (46.60–64.47) | 60.50 (52.70–65.30) | 39.60 (30.70–52.05) | 42.00 (27.40–54.70) | <0.01 |
| V max (m/s) | 4.70 (4.21–5.26) | 4.73 (4.24–5.30) | 4.62 (4.09–5.18) | 4.40 (3.90–4.86) | 0.01 |
| MPG (mm Hg) | 51.00 (41.00–65.00) | 52.00 (42.00–66.00) | 47.50 (38.00–61.00) | 41.00 (31.50–55.50) | <0.01 |
| AVA (m2) | 0.60 (0.46–0.77) | 0.62 (0.47–0.78) | 0.51 (0.40–0.68) | 0.58 (0.42–0.78) | <0.01 |
| BAV (%) | 390 (48.87) | 338 (51.13) | 43 (42.16) | 9 (25.71) | <0.01 |
Values are median (interquartile range), n (%), or mean SD.
AF, atrial fibrillation; AVA, aortic valve area; BAV, bicuspid aortic valve; BMI, body mass index; CABG, coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MPG, mean pressure gradient; N, number; NYHA, New York Heart Association; PCI, percutaneous coronary intervention; PVD, peripheral vascular diseases; STS, Society of Thoracic Surgeons; V max, peak aortic velocity.