Table 3.
Summary of DNA methyltransferase inhibitors.
| Substance Group | Drug Name | Target |
|---|---|---|
| Nucleoside analogs | Decitabine (5-aza-2’-deoxycytidine, Dacogen R, DAC) | DNMT1 and DNMT3A |
| Azacitidine (5-azacytidine, Vidaza R) | DNMT | |
| 5-Fluoro-2′-deoxycytidine (FdCyd) | DNMT1 | |
| CC-486 | DNMT | |
| Guadecitabine (SGI-110) | DNMT | |
| 4′-thio-2′-deoxycytidine (TdCyd) | DNMT1 | |
| Sinefungin | DNMT | |
| Zebularine | DNMT1, CDA | |
| Non-nucleoside analogs | Nanaomycin A | DNMT3B |
| MG98 | DNMT1 | |
| 1-Hydrazinophthalazine | DNMT | |
| CBC12 | DNMT | |
| Epigallocatechin gallate (EGCG) | DNMT | |
| Procainamide | DNMT1 | |
| Psammaplin A | DNMT, HDAC | |
| RG 108 | DNMT1 | |
| SGI-1027 | DNMT1, 3A and 3B | |
| Thioguanine | DNMT | |
| MC3343 | DNMT1 | |
| MC3353 | DNMT1 | |
| BIX-01294 | DNMT3A, DNMT1 and G9a |
DNMT, DNA methyltransferase; CDA, cytidine deaminase; HDAC, histone deacetylase.