Table 5.
Radiosensitivity related genes regulated by DNA methylation in NSCLC.
| Gene | Methylation site | NSCLC Cell line | Methylation status | Response to RT | Gene function |
|---|---|---|---|---|---|
| PTEN | Promoter | H1299 | Hypermethylation | Resistant | Suppressing DNA damage repair, re-oxygenation |
| MicroRNA-9 gene | Promoter | A549 | Hypermethylation | Resistant | Suppressing DNA damage repair |
| OTUD4 | Promoter | A549, H460 | Hypomethylation | Sensitive | Suppressing DNA damage repair |
| SERPINB5 | Promoter | H1299 | Hypermethylation | Resistant | Suppressing tumor cells proliferation |
| TM4SF4 | Promoter + 5′-UTR | A549, Calu-3 | Hypomethylation | Resistant | Promoting tumor cells proliferation |
| IGFBP-3 | Promoter | Sample from patients | Hypomethylation | Resistant | Promoting tumor cells proliferation |
| S100A6 | Promoter | H1299 | Hypermethylation | Resistant | Modulating cell cycle |
| Dab2 | Promoter | LK2 | Hypermethylation | Sensitive | Inhibition of Wnt pathway |
NSCLC, non-small cell lung cancer; RT, radiotherapy; 5′-UTR, 5’ untranslated region.