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Proposed mechanism on PS1 mutant elevating Aβ42/40 ratio by impairing ACE maturation. ACE maturation/glycosylation is essential for its Aβ42-to-Aβ40-and angiotensin-converting activities and for reducing Aβ42/40 ratio. PS1 deficiency inhibits ACE maturation and both of these activities. PS1 mutant selectively inhibits Aβ42-to-Aβ40-converting activity of ACE and elevates Aβ42/40 ratio. However, PS1 mutants do not inhibit angiotensin converting activity of ACE.
