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. 2023 Mar 2;13:3505. doi: 10.1038/s41598-023-30562-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CRYSOL fitting of crystal structure (PDB: 1GRI) to experimental SAXS scattering profiles. SAXS profiles of the purified monomer and dimer from GRB2 WT and mutants are superimposed with theoretical profiles generated by CRYSOL of either monomer or dimer (orange) from the crystal structure (PDB: 1GRI) or the proposed SH2/SH2-mediated domain-swapped dimer model (blue). (A) WT monomer versus 1GRI monomer; (B) N188D/N214D monomer versus 1GRI monomer; (C) V123D putative monomer versus 1GRI monomer; (D) WT dimer versus 1GRI (SH2/C-SH3) domain-swapped dimer or SH2/SH2 domain-swapped dimer; (E) N188D/N214D dimer versus 1GRI dimer or SH2/SH2 domain-swapped dimer; and (F) V122P/V123P putative dimer versus 1GRI dimer or SH2/SH2 domain-swapped dimer.

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