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. 2023 Mar 2;13:3505. doi: 10.1038/s41598-023-30562-7

Figure 4.

Figure 4

CRYSOL fitting of crystal structure (PDB: 1GRI) to experimental SAXS scattering profiles. SAXS profiles of the purified monomer and dimer from GRB2 WT and mutants are superimposed with theoretical profiles generated by CRYSOL of either monomer or dimer (orange) from the crystal structure (PDB: 1GRI) or the proposed SH2/SH2-mediated domain-swapped dimer model (blue). (A) WT monomer versus 1GRI monomer; (B) N188D/N214D monomer versus 1GRI monomer; (C) V123D putative monomer versus 1GRI monomer; (D) WT dimer versus 1GRI (SH2/C-SH3) domain-swapped dimer or SH2/SH2 domain-swapped dimer; (E) N188D/N214D dimer versus 1GRI dimer or SH2/SH2 domain-swapped dimer; and (F) V122P/V123P putative dimer versus 1GRI dimer or SH2/SH2 domain-swapped dimer.