Table 5.
In vitro interaction between A11 peptide and nisin against 10 drug-resistant Salmonella enterica strains.
| Strains | MIC (µg/ml) | CI | Interpretation | ||||
|---|---|---|---|---|---|---|---|
| MIC (alone) | MIC (combination) | ||||||
| A11 | Nisin | A11 | Nisin | ||||
| S. Typhimurium | ATCC13311 | 15.63 | 16,000 | 3.91 | 4000 | 0.500 | Synergy |
| S. Typhimurium | H1-001 | 62.5 | > 16,000 | 31.25 | 500 | 0.516 | Synergy |
| S. Typhimurium | H1-006 | 125 | > 16,000 | 31.25 | 500 | 0.266 | Synergy |
| S. Typhimurium | H1-011 | 62.5 | > 16,000 | 31.25 | 500 | 0.516 | Synergy |
| S. Typhimurium | H1-015 | 62.5 | > 16,000 | 31.25 | 500 | 0.516 | Synergy |
| S. Typhimurium | H1-041 | 125 | > 16,000 | 31.25 | 500 | 0.266 | Synergy |
| S. Typhimurium | H1-062 | 125 | > 16,000 | 31.25 | 500 | 0.266 | Synergy |
| 4,5,12:i:- | H1-100 | 62.5 | > 16,000 | 31.25 | 500 | 0.516 | Synergy |
| 4,5,12:i:- | H2-039 | 62.5 | > 16,000 | 31.25 | 500 | 0.516 | Synergy |
| 4,5,12:i:- | H2-042 | 62.5 | > 16,000 | 15.63 | 500 | 0.266 | Synergy |
| 4,5,12:i:- | H2-089 | 62.5 | > 16,000 | 15.63 | 500 | 0.266 | Synergy |
At MIC value of > 16,000 µg/ml, a value of 32,000 µg/ml was used to calculate the combination index (CI).