Table 3.
Regulation of lncRNA in metabolic disease
| Diseases | Major regulator | Target gene | Effect | References |
|---|---|---|---|---|
| T1D | lncRNA SRAs | miR-146b | ↑ | 260 |
| T2D | lncRNA MALAT1 | Nrf2, JNK, Akt, IRS-1 | ↓ | 261 |
| GDM | lncRNA HOTTIP | WNT7A | ↓ | 262 |
| DKD | lncRNA MALAT1 | LIN28A | ↑ | 263 |
| DR | lncRNA ZNF503-AS1 | TGF-β | ↑ | 264 |
| diabetic wound healing | lncH19 | p53, GDF15 | ↑ | 265 |
| Obesity | lncRNA RP11-142A22.4 | miR-587 | ↑ | 266 |
| Obesity | lnc13728 | ZBED3 | ↑ | 267 |
| Obesity | lncH19 | miR-30a | ↑ | 268 |
| Obesity | lncFR332443 | RUNX1, MAPK | ↓ | 269 |
| Obesity | lncRNA MIR99AHG | miR-29b-3p | ↑ | 270 |
| Obesity | lncRNA U90926 | PPARγ, PPARγ2 | ↓ | 271 |
| Obesity | lncRNA XIST | C/EBPα | ↓ | 272 |
| Obesity | FOXC2-AS1 | UCP1 | ↓ | 273 |
| NAFLD | LncRNA Gm15622 | miR-742-3p | ↑ | 274 |
| NAFLD | Hilnc | IGF2BP2 | ↑ | 275 |
| NAFLD | lncRNA MALAT1 | CXCL5 | ↑ | 276 |
| NAFLD | lncRNA NEAT1 | miR-122 | ↑ | 277 |
| NAFLD | lncRNA HULC | MAPK | ↑ | 278 |
| NAFLD | lncRNA-Gm9795 | TNF, IL-6, and IL-1 | ↑ | 279 |
| NAFLD | lncRNA Platr4 | NF-κB | ↓ | 280 |
| Osteoporosis | lncRNA MIAT | miR-150-5p | ↑ | 281 |
| Osteoporosis | lncRNA RAD51-AS1 | YBX1 | ↓ | 282 |
| Osteoporosis | lncRNA TCONS_00072128 | caspase 8 | ↑ | 283 |
| Osteoporosis | lncRNA TUG1 | Hippo | ↓ | 284 |
| Osteoporosis | LncDIF | miR-489-3p | ↑ | 285 |
| Osteoporosis | LncNEAT1 | Smurf1 | ↓ | 286 |
| Osteoporosis | lncRNA LIOCE | Osterix | ↓ | 287 |
| Osteoporosis | lncRNA NRON | NFATc1 | ↓ | 288 |
| Osteoporosis | lncAK077216 | NIP45 | ↑ | 289 |