Table 4.

Annual changes in eGFR according to the cause of CKD.

	Annual changes of eGFR (mL/min/1.73 m2 per year)
	Unadjusted		Adjusted¶
	Estimate (SE)	P value	Estimate (SE)	P value
Cause of CKD		< 0.001a		< 0.001a
Glomerulonephritis	− 2.19 (0.106)		− 2.16 (0.106)
Hypertensive nephropathy	− 1.44 (0.151)	< 0.001b	− 1.42 (0.152)	< 0.001b
Diabetic nephropathy	− 3.17 (0.16)	< 0.001b < 0.001c	− 3.07 (0.161)	< 0.001b < 0.001c
Polycystic kidney disease	− 3.45 (0.155)	< 0.001b < 0.001c 0.201d	− 3.37 (0.156)	< 0.001b < 0.001c 0.176d

^¶Adjusted with age, sex, body mass index, CKD stage, mean blood pressure, cardiovascular disease, hemoglobin, uric acid, calcium, phosphorous, albumin, total cholesterol, high-density lipid cholesterol, low-density lipid cholesterol, fasting blood sugar, intact parathyroid hormone, urine protein-to-creatinine ratio, high sensitivity C-reactive protein, diuretics use, statin use, and ACE inhibitor or ARB use.

^aP value for the interaction term between the cause of CKD and time effect in the mixed model.

^bP value for each estimated of CKD causes compared to the glomerulonephritis as reference.

^cP value for each estimated of CKD causes compared to the hypertensive nephropathy as reference.

^dP value for each estimated of CKD causes compared to the diabetic nephropathy as reference.

ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; SE, Standard error.