Table 2.

Treatment-related adverse events.

Adverse Events	Any grade n(%)	Grade1-2 n(%)	Grade 3 n(%)	Grade 4 n(%)
Total	142 (84.0)	103 (60.9)	32 (18.9)	7 (4.1)
Fatigue	40 (23.7)	34 (20.1)	6 (3.6)	–
Decreased appetite	39 (23.1)	30 (17.8)	9 (5.3)	–
Fever	52 (30.8)	50 (29.6)	2 (1.2)	–
Nausea	30 (17.8)	24 (14.2)	6 (3.6)	–
Vomiting	18 (10.7)	15 (8.9)	3 (1.8)	–
Abdominal pain	20 (11.8)	18 (10.7)	2 (1.1)	–
Hand-foot syndrome	24 (14.2)	19 (11.2)	4 (2.4)	1 (0.6)
Diarrhea	21 (12.4)	21 (12.4)	–	–
Hypertension	46 (27.2)	36 (21.3)	10 (5.9)	–
Proteinuria	18 (10.7)	12 (7.1)	5 (2.9)	1 (0.6)
Skin rash	19 (11.2)	13 (7.7)	4 (2.4)	2 (1.1)
Thrombocytopenia	24 (14.2)	24 (14.2)	–	–
Hypothyroidism	28 (16.6)	22 (13.0)	6 (3.6)	–
Abnormal liver function	105 (62.3)	86 (50.9)	16 (9.5)	3 (1.9)