Table 5.
Association of age, childhood vaccination and HIV status with disease severity among confirmed monkeypox cases.
| Disease severity |
UnivariableOR (95% CI) | Multivariable OR (95% CI) | ||
|---|---|---|---|---|
| Non-severe (n = 120) | Severe (n = 35) | |||
| Age (median, IQR) | 38.5 [33.0–45.3] | 40.0 [34.5–46.5] | 0.98 (0.94–1.02) | 0.92 (0.92–1.02) |
| Childhood smallpox vaccination (self-reported or scar) | ||||
| Unvaccinated, n (%) | 82 (68.3%) | 23 (65.7%) | Reference | Reference |
| Vaccinated, n (%) | 18 (15.0%) | 7 (20.0%) | 0.72 (0.28–2.04) | 1.36 (0.35–5.89) |
| Unknown, n (%) | 20 (16.7%) | 5 (14.3%) | 0.72 (0.28–2.04) | 1.63 (0.51–6.13) |
| HIV status | ||||
| Negative, n (%) | 75 (62.5%) | 17 (48.6%) | Reference | Reference |
| Positive, n (%) | 39 (32.5%) | 14 (40.0%) | 0.63 (0.28–1.43) | 0.66 (0.28–1.54) |
| Unknown, n (%) | 6 (5.0%) | 4 (11.4%) | 0.34 (0.09–1.45) | 0.33 (0.08–1.43) |
aSevere disease was defined as >100 skin lesions, proctitis requiring opioid analgesics, complications (penile oedema with/without paraphimosis, bacterial skin infection), WHO performance status of 2 or higher, or need for hospitalization.