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Regulation of the MICAL’s activity. (A) Plexins and GTP-bound Rab proteins bind the MICAL’s ERM α-like domain to relieve the MICAL’s autoinhibition. PAK1 kinases also play a role in relieving the MICAL’s autoinhibition by phosphorylating residues within the MICAL’s C-terminus. (B) Rabs and Coronin 1C are involved in the MICAL’s translocation and positioning. Myosin15 is involved in moving the MICAL’s into a new region to propagate its F-actin disassembly effects.
