Table 2.

Epigenetic changes and associated proteins

Epigenetic modification	Associated protein	Function	Reference
Maintenance DNA methylation	DNMT1	Maintain the pattern of DNA methylation	(Klein et al., 2011)
De novo DNA methylation	DNMT3A, DNMT3B	Methylation of unmodified DNA	(Spencer et al., 2017)
DNA demethylation	TET1, TET2, TET3	Remove methylation	(Ponciano-Gómez et al., 2017)
Histone acteylation	p300/CBP	Transcription activation	(Benton et al., 2017)
Histone deacetylation	HDACs	Transcriptional regulation	(Li and Seto, 2016)
H3K4 methylation	SET1	Transcription activation	(Zaidi et al., 2013)
H3K9 methylation	EZH2, G9a/GLP	Transcription repression	(Iacono et al., 2018)
H3K27 methylation	PRC2	Transcription repression (H3K27me1 is associated with transcription activiation)	(Huang et al., 2021)
H3K79 methylation	DOT1L	Transcription activation	(Johnson et al., 2009)
RNA methylation	METTL3, METTL14, WTAP	Installation of m6A on RNA residue	(Ma et al., 2017)
	YTHDF1/2/3, YTHDC1	Binding with m6A	(Paris et al., 2019)
RNA demethylation	FTO, ALKBH5	Remove of m6A on RNA residue	(Zhang et al., 2016)