Table 1.
Current single-cell analysis-based studies on chronic inflammatory diseases
| Inflammatory disease | Species | Tissue | Single-cell analysis techniques | Reference |
|---|---|---|---|---|
| Ankylosing spondylitis | Human | PBMC | Transcriptome, epigenome | (Xu et al., 2021) |
| Human | PBMC | Transcriptome, surface proteome analysis | (Alber et al., 2022) | |
| Human | PBMC, SFMC | Transcriptome, immune repertoire analysis | (Simone et al., 2021) | |
| Inflammatory bowel diseases | Human | Intestinal epithelium, lamina propria from terminal ileum resections | Transcriptome | (Jaeger et al., 2021) |
| Human | Lamina propria from ileum, PBMC | Transcriptome | (Martin et al., 2019) | |
| Human | Rectum, PBMC | Immune repertoire analysis | (Boland et al., 2020) | |
| Human | Colonic biopsies | Transcriptome (both single cell and spatial) | (Garrido-Trigo et al., 2022) | |
| Multiple sclerosis | Human | Cerebrospinal fluid, PBMC | Transcriptome | (Schafflick et al., 2020) |
| Human | Post mortem brain tissue, PBMC | Transcriptome (both single cell and spatial), epigenome | (Kaufmann et al., 2021) | |
| Human | Post mortem brain tissue | Transcriptome | (Absinta et al., 2021) | |
| Mouse | CD11b+ myeloid cell from spleen | Transcriptome | (Lu et al., 2020) | |
| Mouse | MOG-specific CD4+ T cells | Transcriptome | (Krienke et al., 2021) | |
| Mouse | Memory-phenotype CD4+ T cells |
Transcriptome, immune repertoire analysis | (Cho et al., 2022) | |
| Chronic inflammatory skin diseases | Human | Skin biopsies | Transcriptome, epigenome | (Liu et al., 2022b) |
| Human | Skin biopsies | Transcriptome | (Nakamizo et al., 2021) | |
| Human | Skin biopsies | Transcriptome | (Kim et al., 2021) | |
| Human | Skin biopsies | Transcriptome (single cell and spatial) | (Schäbitz et al., 2022) | |
| Rheumatoid arthritis | Human | Synovial biopsies | Transcriptome | (Zhang et al., 2019) |
| Human | Synovial biopsies, PBMC | Transcriptome | (Wu et al., 2021) | |
| Human | Synovial fluid, PBMC | Immune repertoire analysis | (Argyriou et al., 2022) | |
| Human | Synovial biopsies | Transcriptome | (Edalat et al., 2022) | |
| Mouse | CD4+ T cells from lymph node, spleen | Immune repertoire analysis | (Ashouri et al., 2022) | |
| Systemic lupus erythematosus | Human | PBMC | Transcriptome | (Nehar-Belaid et al., 2020) |
| Human | PBMC | Transcriptome | (Guo et al., 2022) | |
| Human | PBMC | Transcriptome, eQTLs | (Perez et al., 2022) | |
| Mouse | B cells from spleen | Transcriptome, immune repertoire analysis | (Zheng et al., 2022) | |
| Primary Sjögren’s syndrome | Human | PBMC | Immune repertoire analysis | (Hou et al., 2022) |
| Human | PBMC | Transcriptome | (Hong et al., 2021) | |
| Human | Labial minor salivary gland biopsies | Transcriptome (both single cell and spatial) | (Nayar et al., 2022) | |
| Mouse | Submandibular gland | Transcriptome | (Horeth et al., 2021) | |
| Type 1 diabetes mellitus | Human | Pancreatic islet, PBMC | Transcriptome, epigenome | (Chiou et al., 2021) |
| Human | Pancreatic islet | Transcriptome | (Fasolino et al., 2022) | |
| Mouse | Pancreatic islet | Transcriptome | (Zakharov et al., 2020) |
PBMC, peripheral blood mononuclear cell; SFMC, synovial fluid mononuclear cell; MOG, myelin oligodendrocyte glycoprotein; eQTLs, expression quantitative trait loci.