Fig. 2. Intrinsic disorder predisposition of neurodegenerative-disease-causing proteins evaluated using the Predictor of Natural Disordered Regions (www.pondr.com/). Domain architecture of tau, α-syn, ATXN2, TDP-43, FUS, and ANXA11. The following domains are indicated in tau: N1 and N2 (N-terminal domains); P1 and P2 (proline-rich region); R1, R2, R3, and R4 (repeated sequences at the microtubule-binding domain). The six proteins share similar domain architectures and protein disorders. ANX, annexin domain; ANXA11, annexin A11; ATXN2, ataxin-2; Aβ, amyloid-beta; FUS, fused in sarcoma; LCD, low-complexity domain; Lsm, Like-Sm; Lsm AD, Lsm-associated domain; NAC, non-Aβ component; NLS, nuclear localization signal; NTD, N-terminal domain; PAM2, PABP-interacting motif 2; polyQ, polyglutamine domain; QGSY, QGSY-rich prion-like domain; RBPs, RNA-binding proteins; RGG, RGG-rich domain; RRM, RNA recognition motif; RRM1, RNA-recognition motif 1; RRM2, RNA-recognition motif 2; TDP-43, TAR DNA-binding protein 43; UPS, ubiquitin proteasome system; ZnF, zinc finger; α-syn, α-synuclein.