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Exposure–Toxicity Association
Mean plasma concentrations of alectinib before and after dose reduction due to bradycardia. The Roman numerals indicate the grade of severity of bradycardia. Plus means the bradycardia improved, minus means the bradycardia remained unchanged or worsened. A sample before dose reduction was not available for all patients. Patient 4 developed grade 2 bradycardia after a first dose reduction for a grade 3 rash.
