Figure 6.

Plasma Exposure per Toxicity Group

This figure shows the difference in alectinib minimal plasma concentration (Ctrough) between patients with (blue dots) and without severe toxicity (red squares) when treated with alectinib 600 mg twice daily. The green triangles are Ctrough concentrations from patients with severe toxicity who were reduced in alectinib dose to 450 mg twice daily because of severe toxicity. Data shown as mean ± SD. ∗P < 0.05; ns = not statistically significant. The dotted line at 435 ng/mL shows the therapeutic threshold of alectinib.