Table 2.

Summary of Adverse Events Related to Alectinib

	Any Grade (N = 53)	Grade ≥3 (n = 26)
Preferred term adverse event
Bradycardia	22 (42)
Myalgia	16 (30)
Edema	7 (13)
Preferred term for severe adverse events
CK elevation	9 (17)	3 (6)
AST/ALT increase	5 (9)	3 (6)
Bradycardia	6 (11)	1 (2)
Myalgia	6 (11)	—
Creatinine increase	3 (6)	—
Blood bilirubin increase	2 (4)	2 (4)
Skin rash	2 (4)	2 (4)
Fatigue	1 (2)	—
Edema	2 (4)	—
Pneumonitis	1 (2)	—
Severe toxicity consequence
Hospital admission	1 (2)
Dose reduction	25 (47)
Treatment interruption	17 (32)
Treatment termination	2 (4)

Values are n (%).

AST = aspartate aminotransferase; ALT = alanine aminotransferase; CK = creatine kinase.