Table 1.
Baseline Characteristics
| All (N = 961) |
FH Mutation (+) (n = 699) |
FH Mutation (−) (n = 262) |
P Value | |
|---|---|---|---|---|
| Age, y | 52 ± 16 | 50 ± 16 | 56 ± 15 | 3.90 × 10-7 |
| Male | 449 (46.7) | 328 (46.9) | 121 (46.2) | 0.8946 |
| Body mass index, kg/m2 | 23.0 ± 0.6 | 22.8 ± 0.6 | 23.3 ± 0.6 | 0.18 |
| Hypertension | 276 (28.7) | 213 (30.5) | 63 (24.0) | 0.06 |
| Diabetes | 83 (8.6) | 69 (9.9) | 14 (5.3) | 0.036 |
| Total cholesterol, mg/dL | 319 (287-360) | 323 (290-372) | 304 (278-334) | 3.40 × 10-8 |
| Triglycerides, mg/dL | 125 (84-173) | 122 (78-168) | 142 (105-178) | 4.70 × 10-5 |
| HDL cholesterol, mg/dL | 47 (40-57) | 46 (39-56) | 49 (41-59) | 0.02334 |
| LDL cholesterol at baseline, mg/dL | 234 (206-279) | 251 (216-292) | 209 (196-229) | <2.20 × 10-16 |
| LDL cholesterol at follow-up, mg/dL | 110 (93-131) | 117 (99-137) | 93 (82-110) | <2.20 × 10-16 |
| History of prior CVD | 294 (30.6) | 238 (34.0) | 56 (21.4) | 0.0002 |
| Lifestyle characteristics | ||||
| Healthy dietary pattern | 740 (77.0) | 527 (75.4) | 213 (81.3) | 0.06419 |
| Regular exercise | 451 (46.9) | 311 (44.5) | 140 (53.4) | 0.01634 |
| Not smoking | 660 (68.7) | 491 (70.2) | 169 (64.5) | 0.1031 |
| Absence of obesity | 864 (89.9) | 632 (90.4) | 232 (88.5) | 0.4626 |
| Lifestyle score | 2.8 ± 0.9 | 2.8 ± 0.9 | 2.9 ± 0.9 | 0.2533 |
| Favorable | 243 (25.3) | 176 (25.2) | 67 (25.5) | 0.9667 |
| Intermediate | 374 (38.9) | 262 (37.5) | 112 (42.7) | 0.1566 |
| Unfavorable | 344 (35.8) | 261 (37.3) | 83 (31.7) | 0.1201 |
Values are mean ± SD, n (%), or median (IQR).
CVD = cardiovascular disease; FH = familial hypercholesterolemia; HDL = high-density lipoprotein; LDL = low-density lipoprotein.