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. 2022 Dec 29;14(9):mjac078. doi: 10.1093/jmcb/mjac078

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© The Author(s) (2022). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dio3 DNA recombination and hormonal profiles in Pomc-cre/Dio3^f/fmice. (A) PCR and qPCR results showing the presence (left) and the abundance (right) of the recombinant Dio3 allele. (B) GFP-labelled cells showing cre-mediated recombination in the hypothalamic arcuate nucleus (n = 3). (C) Serum and pituitary endpoints of the hypothalamic–pituitary–thyroid axis. (D) Serum and pituitary endpoints of the hypothalamic–pituitary–adrenal axis. *P < 0.05 as determined by unpaired Student's t-test.