Scheme 1.

A) Schematic representation of integrated ^IRF‐5SiRNA/M@pMn nanozymes. Polyethyleneimine (PEI) was used to modify Mn₃O₄ to form pMn. The siRNA was then loaded into the pMn, generating ^IRF‐5SiRNA/pMn. The surface of pMn was coated with a neutrophil‐like membrane ( ^IRF‐5SiRNA/M@pMn). B) Schematic diagram of the multifunctional therapeutic ability of the prepared nanozymes that play the main function; macrophages reprogramming and redox modulatory. The multifunctional nanozyme was blended into a gelatin‐based hydrogel for T9 spinal cord transplantation. C) Diagram showing the recruitment of ^IRF‐5SiRNA/M@pMn to inflammatory macrophages.