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Stereoview of stop codon 5′-UAA-3′ (blue) bound to the human release factor eRF1 N-terminal domain (purple) in the reverse orientation to the previously proposed model (10). Only the backbone atoms of eRF1 and the side chain interacting with the trinucleotide are displayed. Green dotted lines indicate possible dipolar interactions conferring binding specificity to the stop codon.
