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. 2023 Feb 13;14(5):917–935. doi: 10.1021/acschemneuro.2c00779

Figure 11.

Figure 11

Dosing regimen to assess effects of EU93-108 on tolerant mice. TIT = tail immersion test. All mice received morphine or saline three times a day according to the protocol in Figure 9. Doses of morphine are shown above the arrows, in mg/kg. Once tolerance was established on day 4, the mice were randomly assigned to receive vehicle, EU93-108, or ifenprodil once a day for two consecutive days. TIT was conducted at the same time points as in Figure 9 and 30 min after injection on days 5 and 6.