Table 2. P Values for Tolerance Development Experiments (Figure 9)^a.

comparison	paired or unpaired?	unadjusted p value	Bonferroni-corrected p value	significant after adjustment?
Male Mice
day 4 108/mor - day 1 108/mor	paired	0.0004	0.0016	yes
day 4 veh/mor - day 1 veh/mor	paired	0.0043	0.0172	yes
day 4 ifen/mor - day 1 ifen/mor	paired	0.139	0.558	no
day 4: 108/mor - veh/mor	unpaired	0.118	0.47	no
Female Mice
day 4 108/mor - day 1 108/mor	paired	0.0317	0.127	no
day 4 veh/mor - day 1 veh/mor	paired	0.0156	0.0624	no
day 4 ifen/mor - day 1 ifen/mor	paired	0.0003	0.0012	yes
day 4: 108/mor - veh/mor	unpaired	0.553	2.21	no

^aFor male and female mice, all relevant comparisons were analyzed using paired or unpaired Student’s t-tests as appropriate. t-tests were followed by Bonferroni correction where each p-value was multiplied by the total number of comparisons made, yielding an adjusted p-value. We also indicated whether the adjusted p-values were significant (<0.05).