Table I.
Comparison of serum levels according to clinicopathological characters of the patients with esophageal carcinoma using univariate analysis.
| Variable | WDR1-Ab >1865 | WDR1-Ab ≤1865 | P-value |
|---|---|---|---|
| Sex | |||
| Male | 24 | 46 | 0.012 |
| Female | 14 | 7 | |
| Age, years | |||
| >65 | 22 | 31 | >0.999 |
| ≤65 | 16 | 22 | |
| Tumor location | |||
| Upper | 5 | 9 | 0.771 |
| Lower | 33 | 44 | |
| Tumor depth | |||
| T1 | 15 | 14 | 0.254 |
| T2-T4 | 23 | 39 | |
| Lymph node metastasis | |||
| N0 | 17 | 24 | >0.999 |
| N1 | 21 | 29 | |
| Tumor stage | |||
| 0 | 6 | 3 | |
| I | 6 | 8 | |
| II | 8 | 17 | |
| III | 16 | 18 | |
| IV | 2 | 7 | |
| SCC-Ag (ng/ml) | |||
| >1.5 | 10 | 21 | 0.260 |
| ≤1.5 | 27 | 31 | |
| p53-Ab (U/ml) | |||
| >1.30 | 7 | 10 | >0.999 |
| ≤1.30 | 29 | 43 | |
| WBC (/µl) | |||
| >8,000 | 4 | 7 | 0.757 |
| ≤8,000 | 34 | 46 | |
| Neutrophils (%) | |||
| >70 | 8 | 11 | >0.999 |
| ≤70 | 30 | 42 | |
| Lymphocytes (%) | |||
| >35 | 6 | 11 | 0.597 |
| ≤35 | 32 | 42 | |
| Hemoglobin (g/dl) | |||
| >12 | 25 | 36 | >0.999 |
| ≤12 | 13 | 17 | |
| Platelets (/µl) | |||
| >150,000 | 37 | 36 | 0.232 |
| ≤150,000 | 1 | 6 | |
| CRP (mg/dl) | |||
| >0.3 | 10 | 19 | 0.370 |
| ≤0.3 | 27 | 33 | |
| Albumin (g/dl) | |||
| >3.5 | 29 | 39 | 0.811 |
| ≤3.5 | 9 | 14 |
Fisher's exact probability test was used for statistical analysis. Stage was determined using the Classification by the Japan Esophageal Society (36). As regards tumor location, the oral side from the tracheal bifurcation was defined as the ‘upper’ location and the anal side from the tracheal bifurcation was defined as the ‘lower’ location. WDR1, WD repeat-containing protein 1; WDR1-Ab, serum anti-WDR1 antibody; N0, no lymph node metastasis; N1, lymph node metastasis exists; SCC-Ag, squamous cell carcinoma antigen; WBC, white blood cell; CRP, C-reactive protein. There were some cases for which SCC-Ag, p53-Ab and CRP were not measured.