Table 7.
Infections in Pre- and Post-Intervention Cohorts
| |
Pre-intervention cohort (n = 139) |
Post-intervention cohort (n = 126) |
Absolute change |
Relative change |
|
||
|---|---|---|---|---|---|---|---|
| Endpoint |
n
|
% |
n
|
% |
% |
% |
p
|
| Number of patients with infections at 30 daysa | |||||||
| Any related infection | 37 | 26.6 | 18 | 14.3 | −12.3 | −46.3 | 0.013 |
| Any SSI | 19 | 13.7 | 6 | 4.8 | −8.9 | −65.2 | 0.013 |
| Superficial SSI | 14 | 10.1 | 3 | 2.4 | −7.7 | -76.2 | 0.011 |
| Deep SSI | 5 | 3.6 | 3 | 2.4 | −1.2 | −33.3 | 0.725 |
| Intra-abdominal infection | 17 | 12.2 | 12 | 9.5 | −2.7 | −22.1 | 0.481 |
| Related empyema | 4 | 2.9 | 2 | 1.6 | −1.3 | −44.8 | 0.686 |
| Related SSTI | 4 | 2.9 | 1 | 0.8 | -2.1 | −72.4 | 0.373 |
| Secondary blood stream infection | 2 | 1.4 | 5 | 4.0 | +2.6 | +186 | 0.263 |
| Any related infection other than superficial SSI and minor SSTI | 26 | 18.7 | 14 | 11.1 | −7.6 | −40.6 | 0.085 |
| Any unrelated infection | 38 | 27.3 | 30 | 23.8 | −3.5 | −12.9 | 0.511 |
| Pneumonia | 23 | 16.6 | 16 | 12.7 | −3.9 | −23.3 | 0.377 |
| UTI | 15 | 10.8 | 7 | 5.6 | −5.2 | −48.5 | 0.123 |
| Primary bloodstream infection | 7 | 5.0 | 1 | 0.8 | −4.2 | −84.2 | 0.069 |
| Unrelated SSI or SSTI | 4 | 2.9 | 7 | 5.6 | +2.7 | +93.1 | 0.275 |
| Otherb | 1 | 0.7 | 3 | 2.4 | +1.7 | +231 | 0.349 |
| Clostridiodes difficile-related disease | 5 | 3.6 | 0 | 0.0 | −3.6 | −100 | 0.062 |
| Any related or unrelated infection | 60 | 43.2 | 40 | 31.8 | −11.4 | −26.5 | 0.056 |
| Number of patients with infections at 90 daysa | |||||||
|---|---|---|---|---|---|---|---|
| Any related infection | 42 | 30.2 | 22 | 17.5 | −12.8 | −42.2 | 0.015 |
| Any SSI | 25 | 18.0 | 9 | 7.1 | −10.8 | −60.3 | 0.008 |
| Superficial SSI | 20 | 14.4 | 5 | 4.0 | −10.4 | −72.4 | 0.004 |
| Deep SSI | 6 | 4.3 | 4 | 3.2 | −1.1 | −26.5 | 0.752 |
| Intra-abdominal infection | 18 | 13.0 | 14 | 11.1 | −1.8 | −14.2 | 0.631 |
| Related empyema | 4 | 2.9 | 2 | 1.6 | −1.3 | −44.8 | 0.686 |
| Related SSTI | 5 | 3.6 | 3 | 2.4 | −1.2 | −33.8 | 0.725 |
| Secondary blood stream infection | 2 | 1.4 | 5 | 4.0 | +2.5 | +176 | 0.263 |
| Any related infection other than superficial SSI and minor SSTI | 27 | 19.4 | 16 | 12.7 | −6.7 | −34.6 | 0.139 |
| Any unrelated infection | 45 | 32.4 | 34 | 27.0 | −5.4 | −16.7 | 0.338 |
| Pneumonia | 24 | 17.3 | 16 | 12.7 | −4.6 | −26.5 | 0.300 |
| UTI | 19 | 13.7 | 13 | 10.3 | −3.4 | −24.5 | 0.403 |
| Primary blood stream infection | 10 | 7.2 | 2 | 1.6 | −5.6 | −77.9 | 0.037 |
| Unrelated SSI or SSTI | 5 | 3.6 | 9 | 7.1 | +3.6 | +97.2 | 0.198 |
| Otherc | 2 | 1.4 | 3 | 2.4 | +0.9 | +71.4 | 0.671 |
| Clostridiodes difficile-related disease | 5 | 3.6 | 0 | 0 | −3.6 | −100 | 0.062 |
| Any related or unrelated infection | 67 | 48.2 | 43 | 34.1 | −14.1 | −29.2 | 0.020 |
SSI = surgical site infection; SSTI = skin and soft tissue infection; UTI = urinary tract infection.
a
Patients in either cohort may have had more than one type of infection.
b
Pre-intervention cohort: ocular infection, 1; post-intervention cohort: osteomyelitis, 2; Meningitis, 1.
c
Pre-intervention cohort: ocular infection, 1; osteomyelitis, 1; post-intervention cohort: osteomyelitis, 2; meningitis, 1.