Table 3.

Predictive variable for relapse, LDH, and ESR as AHSCT outcomes by multivariate analysis. COX regression for relapse and Poisson regression for LDH and ESR

Relapse			LDH			ESR
Variables	HR (95% CI)	P value	Variables	Beta	P value	Variables	Beta	P value
miR-125b BE	2.23 (2.12–2.78)	0.01	Intercept	6.65	< 0.0001	Intercept	2.01	0.044
miR-125b BP	6.7 (6.41–7.02)	< 0.001	miR-125b BE	4.79	< 0.0001	miR-125b BE	5.65	< 0.0001
Age	0.24 (0.20–1.02)	0.426	miR-125b BP	8.52	< 0.0001	miR-125b BP	2.41	0.015
Engraftment day	1.04 (0.74–1.91)	0.091	Age	0.35	0.72	Age	1.11	0.267
Diagnosis to transplantation	0.72 (0.57–1.22)	0.372	Weight	2.45	0.064	Weight	1.65	0.098
G-CSF dose for mobilization	0.8 (0.07–1.8)	0.263	Diagnosis to transplantation	1.83	0.067	Chemotherapy Courses	1.48	0.139
CD34+ cell count/kg	1.01 (0.04–1.43)	0.117	Mobilization Days	4.46	< 0.1	WBC count in apheresis	0.92	0.356
			G-CSF dose for mobilization	6.28	0.1	MNC count in apheresis	1.74	0.081
			Pre-apheresis CD34+cell count	1.78	0.074	CD34+ cell count/kg	2.42	0.15
			Total processed blood in Apheresis	3.64	0.12	Conditioning days	1.35	0.177
			MNC count in apheresis	4.01	0.08	Engraftment day WBC count	1.97	0.068
			CD34 + cell count/kg	3.02	0.0026	Engraftment day PLT count	1.63	0.103
			Conditioning days	2.07	0.38	Engraftment Day	2.34	0.19
			Engraftment day	4.50	< 0.0001	miR-155 PE	0.69	0.489
						miR-155 BP	1.26	0.207
						miR-126 BP	1.17	0.07
						miR-126 PP	0.09	0.926

ESR: Erythrocyte sedimentation rate, LDH: Lactate dehydrogenase, EVs: Extracellular vesicles, HR: Hazard ratio, BE: Before mobilization EVs, BP: Before mobilization plasma, PE: Post conditioning EVs, PP: Post conditioning plasma, WBC: White blood cell, MNC: Mono nuclear cell, G-CSF: Granulocyte colony stimulating factor