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Proposed secondary structure of human hTR (17). The structure of human hTR was derived from the phylogenic comparison of 35 different vertebrate telomerase RNAs. Co-variation of potential base pairs in different organisms is used as an indication that a particular stem–loop structure may indeed exist. The template region (nucleotides 46–56) as well as the region complementary to the phosphoramidate oligonucleotide GRN137159 (137–151) have been shaded.
