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. 2023 Mar 2;23:199. doi: 10.1186/s12885-023-10675-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Delineation of the functional states across different macrophage subsets. a t-SNE projection of cluster 0–4 macrophages, colored according to cell identity. b Heatmap showing the normalized single sample gene set enrichment analysis (ssGSEA) score for cancer- and immunological-related gene sets from the MSigDB hallmark collection across different macrophage subsets. c t-SNE projection of normalized ssGSEA score for representative hallmark and immune terms.