Table 1.

Common clinical disease models and animal models in organ fibrosis

Organ	Clinical disease models	Animal models
Lung	Idiopathic pulmonary fibrosis (IPF), radiation induced pulmonary fibrosis	Bleomycin induced pulmonary fibrosis
Heart	Myocardial infarction (MI) cardiomyopathy, chronic heart failure	MI induced cardiac fibrosis, transverse aortic constriction (TAC) induced cardiac fibrosis, Ang-II induced cardiac fibrosis
Liver	Non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) viral hepatitis	CCl4 induced liver fibrosis, thioacetamide (TAA) induced liver fibrosis, bile duct ligation (BDL) induced liver fibrosis
Kidney	Chronic kidney disease (CKD) easpecially diabetic and hypertrophic nephropathy	Ischemia–reperfusion injury (IRI) induced renal fibrosis, unilateral ureteral obstruction (UUO) induced renal fibrosis
Skin	Systemic Sclerosis (SSc), hypertrophic scar and keloid	Bleomycin induced skin fibrosis