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. 2023 Mar 2;15:36. doi: 10.1186/s13148-023-01454-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Selenite treatment altered DNA methylation machinery mainly at the protein level and altered the transcriptomic landscape. A The mRNA levels of DNA methylation machinery treated for 72 h were assessed by RT-qPCR and demonstrated upregulation in DNMT1 and TET1 in H1975 only. B Western blot analysis of H1975 and H358 cell lysate treated for 72 h demonstrated downregulation in DNMT1 and upregulation in TET1. C Heatmap of the differentially expressed genes