Fig. 3.

Selenite treatment was associated with dysregulated classical and non-classical MAPK signaling. A KEGG enrichment of the differentially expressed genes at the transcript resolution of H1975 treated with or without 5.0 µM selenite and H358 treated with or without 2.5 µM selenite for 72 h. B Heatmap of the sequencing data revealed dysregulated classical and non-classical MAPK pathways mainly in H1975 treated with 72 h 5.0 µM selenite. C Western blot analysis of H975 and H358 on ERK and p38 signaling treated for 72 h