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. Author manuscript; available in PMC: 2023 Mar 3.
Published in final edited form as: Cell Rep. 2022 Dec 29;42(1):111934. doi: 10.1016/j.celrep.2022.111934

Figure 6. Cachexia remodels the expression of secreted factors across tissues.

Figure 6.

(A) Expression of secreted factors is regulated across tissues by cancer cachexia.

(B) Comparison of the similarity in the cancer-induced transcriptional changes for secreted factors.

(C) Cachexia-induced secreted factors include cytokines, growth factors, growth factor-binding proteins, and enzymes, such as ACE.

(D) ACE expression progressively increases in the TA muscle during cancer-induced wasting. SD with **p < 0.01 and ***p < 0.001.

(E) Western blots indicate that cachexia increases ACE protein levels in TA muscles. SEM with *p < 0.05 and n = 4–5.

(F) ACE expression correlates with that of FBX O 32 (atrogin-1) and TRIM63 (MuRF1) in muscle biopsies from female cancer patients.