Figure 1.

Fundus photographs and swept source OCT angiography images. Color fundus imaging of patient GA2 (A, B) and patient GA3 (C, D) in 1996 and 2016. (A) Patient GA2 has a circular region of central foveal-involving GA with surrounding drusen along the vascular arcades. (B) The region of GA in patient GA2 has enlarged over 10 years with surrounding drusen beyond the vascular arcades. (C) Patient GA3 has an irregular region of GA involving the central macula with surrounding drusen and hyperpigmentation. (D) Over 10 years, the region of GA has enlarged with extension to the peripapillary area along with surrounding drusen and hyperpigmentation. Note that along the superior region of the macula, scarring has resulted from the area with the previous macular hemorrhage. Red-free fundus image and SS-OCTA en face imaging of patient GA2 (E–G) and patient GA3 (H–J) in 2016. (E) Red-free imaging of the same eye as in B. (F) En face sub-RPE structural image showing GA corresponding to the hypertransmission defect (hyperTD) along with surrounding calcified drusen, which correspond to the dark regions or hypotransmission defects (hypoTDs). (G) En face sub-RPE SS-OCTA image showing the large choroidal vessels within the GA lesion that correspond with those shown in the color and red-free fundus photo. (H) Red-free fundus image of the same eye as in D. (I) En face sub-RPE structural image showing a hyperTD that corresponds to GA surrounded by hypoTDs that correspond to calcified drusen. The scarring corresponds to the dark hypoTD since it blocks the light from penetrating into the choroid. (J) En face sub-RPE angiographic image showing the large choroidal vessels within the region of GA that correspond to the choroidal vessels seen in the color and red-free fundus images.