Table 2. Association between the HOMA-IR index and clamp-derived insulin sensitivity index in the pubertal and postpubertal adolescents – multivariable linear regression analysis.

Dependent Variables	Pubertal
	Model	Independent variables	B (SE)	95% CI	β	P-value	R2 for model
ISI, mg/kgLBM/min per mU/L × 100a	1	Constant	−0.355 (0.467)	−1.304 to 0.594	-	0.452	0.539
		HOMA-IR	−0.140 (0.024)	−0.188 to −0.092	−0.725	<0.001	0.701
		Sexb	0.056 (0.122)	−0.192 to 0.304	0.056	0.650
		Age, years	−0.011 (0.033)	−0.78 to 0.055	−0.042	0.728
	2	Constant	0.501 (0.434)	−0.383 to 1.385	-	0.257
		HOMA-IR	−0.087 (0.023)	−0.135 to −0.040	−0.451	0.001
		Sexb	0.206 (0.106)	−0.010 to 0.422	0.206	0.061
		Age, years	−0.005 (0.027)	−0.060 to 0.049	−0.019	0.847
		Waist circumference, cm	−0.013 (0.003)	−0.020 to −0.007	−0.489	<0.001

Dependent Variables	Postpubertal
	Model	Independent variables	B (SE)	95% CI	β	P-value	R2 for model
ISI, mg/kgLBM/min per mU/L × 100a	1	Constant	−0.173 (0.334)	−0.849 to 0.503	-	0.607	0.609
		HOMA-IR	−0.148 (0.020)	−0.188 to −0.109	−0.763	<0.001	0.709
		Sexb	0.064 (0.091)	−0.120 to 0.248	0.073	0.488
		Age, years	−0.024 (0.021)	−0.067 to 0.019	−0.117	0.270
	2	Constant	0.495 (0.346)	−0.205 to 1.195	-	0.160
		HOMA-IR	−0.101 (0.021)	−0.145 to −0.058	−0.522	<0.001
		Sexb	0.114 (0.081)	−0.050 to 0.278	0.130	0.166
		Age, years	−0.025 (0.019)	−0.063 to 0.013	−0.121	0.193
		Waist circumference, cm	−0.009 (0.002)	−0.014 to −0.004	−0.402	0.001

B: unstandardized coefficient; SE: standard error; β: standardized coefficient; CI: confidence interval; HOMA-IR: homeostasis model assessment of insulin resistance; ISI: insulin sensitivity index; LBM: lean body mass.

^aLogarithmic transformation was performed.

^b0 represents the female and 1 the male.