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. 2023 Mar 3;18(3):e0282244. doi: 10.1371/journal.pone.0282244

Fig 1. The expression levels of ABCB1 and p-GP are up-regulated in breast cancer MCF-7/Taxol cells.

Fig 1

A. Expression levels of ABCB1 mRNA in MCF-7 and MCF-7/Taxol cells were determined by qRT-PCR. GAPDH was used as an internal control. B. Expression levels of p-GP in MCF-7 and MCF-7/Taxol cells were determined by Western blotting. C. Cell proliferation was determined by CCK-8 assay after treatment with Taxol at different time- points (24, 48 and 72h). D. MCF-7 and MCF-7/Taxol cells were cultured in regular medium with different Taxol concentrations (60, 120, 180, 240 and 300 nM), cell number was counted after 72 hours of Taxol treatment. Relative growth inhibition was normalized to cell number of MCF-7 cells without Taxol treatment. Data are expressed as the mean ± SD of three independent experiments. ***P<0.001 vs control group.