Table 4.
Summary of pairwise meta–analyzed outcomes
| Outcome | Comparison | Subgroup | Sample size | Number of studies | Pairwise meta–analysis | |||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | I2 | |||||
| Postoperative Morbidity | Surg vs. Stent | – | 10,100 | 27 | 2.14 | 1.56, 2.94 | < 0.01 | 69 |
| RCTs | 447 | 7 | 2.67 | 1.17, 6.08 | 0.02 | 73 | ||
| Observational | 9,653 | 20 | 2.06 | 1.45, 2.92 | < 0.01 | 69 | ||
| Surg vs. Stoma | – | 704 | 8 | 1.11 | 0.54, 2.29 | 0.78 | 76 | |
| RCTs | 195 | 2 | 1.80 | 0.94, 3.45 | 0.08 | 0 | ||
| Observational | 1,217 | 7 | 0.96 | 0.50, 1.85 | 0.90 | 77 | ||
| Stent vs. Stoma | – | 904 | 8 | 0.61 | 0.39, 0.94 | 0.03 | 29 | |
| Postoperative Mortality | Surg vs. Stent | – | 10,216 | 25 | 1.32 | 0..92, 1.89 | 0.13 | 9 |
| RCTs | 186 | 3 | 0.84 | 0.29, 2.47 | 0.75 | 0 | ||
| Observational | 10,030 | 22 | 1.50 | 0.99, 2.25 | 0.05 | 15 | ||
| Surg vs. Stoma | – | 1,583 | 10 | 1.87 | 0.94, 3.72 | 0.07 | 26 | |
| Stent vs. Stoma | – | 904 | 8 | 0.59 | 0.24, 1.47 | 0.26 | 26 | |
| Anastomotic Leak | Surg vs. Stent | – | 9,900 | 24 | 1.23 | 0.92, 1.64 | 0.17 | 0 |
| RCTs | 448 | 7 | 0.86 | 0.27, 2.71 | 0.80 | 24 | ||
| Observational | 9,452 | 17 | 1.28 | 0.94, 1.74 | 0.11 | 0 | ||
| Surg vs. Stoma | – | 1,222 | 7 | 1.50 | 0.54, 4.18 | 0.44 | 30 | |
| Stent vs. Stoma | – | 706 | 7 | 0.68 | 0.36, 1.32 | 0.25 | 0 | |
| Permanent Stoma | Surg vs. Stent | – | 8,826 | 22 | 2.91 | 2.10, 4.04 | < 0.01 | 33 |
| RCTs | 273 | 5 | 1.82 | 0.62, 5.38 | 0.28 | 44 | ||
| Observational | 8,553 | 17 | 3.16 | 2.30, 4.35 | < 0.01 | 24 | ||
| Surg vs. Stoma | – | 1,156 | 6 | 2.18 | 0.94, 5.07 | 0.07 | 67 | |
| Stent vs. Stoma | – | 719 | 5 | 0.64 | 0.25, 1.65 | 0.35 | 51 | |
| Adjuvant Chemotherapy | Surg vs. Stent | – | 2,800 | 18 | 0.85 | 0.69, 1.03 | 0.10 | 13 |
| RCTs | 281 | 4 | 0.89 | 0.45, 1.74 | 0.73 | 23 | ||
| Observational | 2,519 | 14 | 0.84 | 0.67, 1.04 | 0.11 | 17 | ||
| Surg vs. Stoma | – | 223 | 2 | 5.39 | 1.66, 17.51 | < 0.01 | 0 | |
| Stent vs. Stoma | 719 | 4 | 1.11 | 0.53, 2.33 | 0.77 | 55 | ||
| 3y–OS | Surg vs. Stent | – | 1,413 | 13 | 1.15 | 0.85, 1.55 | 0.36 | 6 |
| RCTs | 201 | 3 | 1.20 | 0.67, 2.15 | 0.53 | 0 | ||
| Observational | 1,212 | 10 | 1.11 | 0.75, 1.64 | 0.62 | 26 | ||
| Surg vs. Stoma | – | 523 | 3 | 0.63 | 0.32, 1.22 | 0.17 | 61 | |
| Stent vs. Stoma | – | 304 | 2 | 0.61 | 0.27, 1.39 | 0.24 | 40 | |
| 5y–OS | Surg vs. Stent | – | 685 | 8 | 0.81 | 0.47, 1.40 | 0.12 | 38 |
| Surg vs. Stoma | – | 337 | 3 | 0.44 | 0.28, 0.71 | < 0.01 | 0 | |
| Stent vs. Stoma | – | 181 | 2 | 0.63 | 0.34, 1.17 | 0.14 | 0 | |
Bold values indicate p < 0.05
y year, OS overall survival, Surg surgery, RCTs randomized controlled trials, OR odds ratio, CI confidence interval