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. 2023 Mar 3;9(9):eabo4616. doi: 10.1126/sciadv.abo4616

Fig. 6. Histological analyses showed the improved ischemic heart function by sEV injection in cardiac IR rats 28 days after treatment.

Fig. 6.

(A) Representative images of picrosirius red–stained heart 28 days after sEV injection. Scale bar, 1 mm. (B) WGA-positive hypertrophy and isolectin B4 (IB4)–positive vessels in ischemic muscles 28 days after sEV injection. Scale bars, 200 μm. (C) Fibrotic area in left ventricular (LV) muscle quantified from picrosirius red–stained images. (D) Cross-sectional area (CSA) and (E) myocyte diameter measured from WGA-stained images. (F) Vessel covered area measured from Isolectin B4–stained images. *P < 0.05, **P < 0.01, ***P < 0.001, and ***P < 0.0001.